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L-thyroxine/T4

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  • Description


Levothyroxine
Alias: T4 ; tetraiodothyronine
CAS NO: 51-48-9
Einecs No: 200-101-1
MF: C15H11I4NO4

MW: 776.87

Purity: 98.0%
Appearance: White crystal. This product soluble in alkali solution, insoluble in water, ethanol and ether.


Specifications:
Test Specifications Result
Appearance Almost white crystalline powder white crystalline powder
Identification
(1)iodine
(2)color

1)flame decomposes andlibetates iodine vapors
2)add solution,a pink colour peoduced

1)Pass
2)Pass
Solubility 1)Very Slightly Soluble in Water
2)Soluble in Solutions of Alkali hydeoxides and in hot solutions of Alkli Carbonates
3)Slightly Soluble in Alcohol
4)Insoluble in Acetone,Chloroform and in Ether
1)Pass
2)Pass
3)Pass
4)Pass
Specific optical rotation -5°~-6°
(Sol 3.0% mixture from NaOH 1N/Ethanol 1:2)
-5.8°
Loss on drying ≤11.0% 9.60%
Liothyronine ≤2.0% 0.8%
Iodide ≤0.08% 0.06%
Assay 97.0%~103.0% 98.6%
Conclusion Conforms to USP30

 
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